Wortmannin（渥曼青霉素，AbMole，M2053）是一种源自真菌的甾体代谢物，作为磷脂酰肌醇3-激酶（PI3K）家族的强效共价抑制剂，能不可逆地结合PI3K催化亚基。Wortmannin还能抑制同属PI3K家族的DNA依赖性蛋白激酶（DNA-PK）和共济失调毛细血管扩张症突变激酶（ATM）。在生物学活性上，Wortmannin（渥曼青霉素，AbMole，M2053） ...

National Human Brain Bank for Development and Function, Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic ...

1 Graduate School, Youjiang Medical University for Nationalities, Baise, China. 2 Department of Orthopedic Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, ...

A UC model was established, and AM extract was orally administered to evaluate its role in the treatment of colitis in mice. The effects of AM extract on colitis mice were subsequently investigated ...

The onset of puberty is increasingly observed at earlier ages in children, especially in girls with obesity, while the molecular basis of this phenomenon remains partially unfolded. Since bile acids ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Owing to its high mortality rate, lung cancer (LC) remains the most common cancer worldwide, with the highest malignancy diagnosis rate. The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) ...

Giamundo et al. present fundamental data with new insights into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling ...