This article examines how exercise-induced exerkines prevent disease, as well as promote metabolic, cardiovascular, immune, ...

Key Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest ...

The canonical Wnt signaling pathway is activated when a Wnt protein binds to a Frizzled receptor and its co-receptor (Figure 1A; Nusse and Clevers, 2017). This interaction results in the recruitment ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with high morbidity and mortality. Empagliflozin, an SGLT2 (sodium–glucose cotransporter 2) inhibitor, reduces adverse ...

Skin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. Central to this process is the overactivation of the mitogen-activated protein kinase (MAPK) ...

Sepsis is a syndrome of inflammatory response syndrome (SIRS) triggered when the host is exposed to bacterial, viruses, and other infectious agents. The resulting inflammation compromises intestinal ...

1 Graduate School, Youjiang Medical College for Nationalities, Baise, China. 2 Department of Otorhinolaryngology—Head and Neck Surgery, Southwest Hospital Affiliated to Youjiang Medical University for ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...