Geographic atrophy (GA) is a severe form of age-related macular degeneration with limited treatment options, affecting millions worldwide. Recent FDA-approved therapies, pegcetacoplan and avacincaptad ...

1 Scientific Department, Wellcomet GmbH, Karlsruhe, Germany 2 Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, United States Hypertrophic scars (HTS) and ...

Dysregulated complement pathways are linked to progression from iAMD to advanced AMD, including NVAMD and GA. Higher systemic levels of C4, C4b, and a reduction in C3 are associated with increased ...

Please provide your email address to receive an email when new articles are posted on . A protein known as granzyme K was recently shown to be a driver of inflammation by activating the complement ...

The alternative complement pathway plays a key role in the pathogenesis of IgA nephropathy. Iptacopan specifically binds to factor B and inhibits the alternative pathway. In this phase 3, double-blind ...

The following is a summary of “Schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking,” published in the September 2024 issue of Psychiatry by Phadke et al.

A growing body of evidence suggests that complement dysregulation plays a role in the pathogenesis of preeclampsia. The kidney is one of the major organs affected in preeclampsia. Because the kidney ...

Objective The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator ...