We developed an assay of T cell activation involving stimulation of highly purified CD4 + T cells with immobilized antibodies against CD3/CD28, in the presence or absence of blocking monomeric Fab ...

本综述深入探讨了CTLA-4 B细胞表位肽疫苗（CTLA-4-Vaxx）的开发及其与PD1-Vaxx或PDL1-Vaxx的联合应用。研究通过工程化嵌合B细胞表位 ...

T cells are the 'foot soldiers' that fight cancer inside the body. Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This 'brake' is a molecule ...

本研究针对CTLA-4抗体治疗中免疫相关不良事件（irAE）严重限制临床应用的问题，开发了一种新型蛋白酶响应型前体抗体ProCTLA-4。通过基质金属蛋白酶（MMP）可切割 linker 设计，该抗体在肿瘤微环境（TME）中被特异性激活，显著降低系统性毒性的同时增强了对调节 ...

To maintain tissue homeostasis under the duress of infection or injury, the immune system is endowed with a diverse repertoire of soluble and cellular effectors. The innate response, composed of ...

一度被打入冷宫的CTLA-4靶点，随着今年诺贝尔奖突然升温。 11月11日，BioNTech举办研发日活动。令到场嘉宾诧异的是，BioNTech ...

As professional antigen presenting cells, dendritic cells balance immune activation and inhibition to maintain immune homeostasis. An important inhibitory molecule expressed by dendritic cells is ...

T cells are the 'foot soldiers' that fight cancer inside the body. Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This 'brake' is a molecule ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not include a full text component.

ROCKVILLE, Md.--(BUSINESS WIRE)--OncoImmune, Inc. announced today that its Investigational New Drug (“IND”) application for ONC-392, its novel, next generation anti-CTLA-4 antibody, has been approved ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 11 (May 27, 2003), pp. 6676-6681 (6 pages) Immunization of mice with two myasthenogenic peptides, ...