A recent review identifies interleukin-36 (IL-36) as a transformative driver of vascular inflammation, revealing that serum concentrations in patients with coronary artery disease (CAD) are ...

Growing neurons rely on chemical cues to find their targets, but new research shows that the brain’s physical properties help ...

Molecularly targeted therapies are increasingly relevant in clinical oncology, as they enable the selective modulation of specific biologic targets—such as enzymes or receptors—by inhibiting or ...

On the occasion of Rare Disease Day, the Biofisika Institute (CSIC, EHU) presents the progress of a project aimed at understanding the molecular origin of CTNNB1 neurodevelopmental syndrome, a rare ...

Under states of cellular stress or inflammatory signaling, investigations indicate that IRR expression may increase, allowing selective ligands such as ARA-290 to initiate downstream signaling.

Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors ...

Five years ago, Nobel laureate Carolyn Bertozzi, PhD, and her team described novel small RNA-glycan conjugates, glycosylated RNAs (glycoRNAs), on the cell surface. These small non-coding RNAs have ...

Scientists have uncovered a previously hidden biological interaction that helps explain why brain cells die in Parkinson’s disease and how that damage might be stopped. Credit: Shutterstock Scientists ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Immunotherapy has revolutionized the way physicians treat patients. Previously, chemotherapy was the standard-of-care with the goal to eliminate tumor cells by dysregulating their ability to ...

The precise spatial organization of cells into functional tissues represents a fundamental challenge in biology and regenerative medicine. Conventional methods for directing cell assembly often lack ...