Researchers at the Kennedy Institute of Rheumatology have found that physically resisting the formation of an immunological synapse actually promotes a stronger immune response. The findings could ...

Macrophages are central to mechanobiology research: their physical characteristics-stiffness, adhesion, and ECM (extracellular matrix) sensing-are inextricably linked to their phenotypic polarization ...

Immunotherapy has revolutionized the way physicians treat patients. Previously, chemotherapy was the standard-of-care with the goal to eliminate tumor cells by dysregulating their ability to ...

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into the ...

AMES, Iowa – Sanjeevi Sivasankar knows a lot about how the healthy cells in your body stick together. He and his research team have studied cell adhesion proteins called cadherins. They’ve developed ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Breast cancer is the second highest diagnosed cancer in women in the US and, as of 2020, the most commonly diagnosed cancer in women worldwide. 1 In 15–20 percent of these cases, the growth factor ...

The MYCN oncoprotein plays a key role in starting, advancing and making it difficult to treat various human cancers. When MYCN is overactive, especially in high-risk neuroblastoma, the tumors become ...

Rather than aligning with classical hematopoietic signaling, the peptide has been theorized to engage selective molecular pathways associated with cellular stress response, immunomodulatory signaling, ...