The GPCRact AI model goes beyond AlphaFold3 by predicting whether drugs functionally activate G-protein-coupled receptors through allosteric signaling.

Preclinical research across multiple cancer types now shows that the NAD+ salvage pathway, the same biological mechanism targeted by popular anti-aging supplements like nicotinamide mononucleotide ...

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or ...

Researchers have uncovered a surprising molecular chain reaction in the brain that may play a role in some forms of autism.

CD25 rewires oncogene signaling in AML and ALL, revealing druggable complexes and a bold strategy: push pathways into toxic ...

GLP-1 drugs may help boost heart attack recovery by lowering the risk of major complications, an animal study suggests.

Cell-based therapy aims to reverse some of this decline by providing the scalp with a concentrated mix of progenitor cells -- immature but highly functional cells that can differentiate into ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or ...

A hidden molecular chain reaction in the brain may push key cellular systems into overdrive in autism—and scientists just found a way to switch it off.

A new study discovers how nitric oxide triggers a biochemical domino effect in the brain, leading to mTOR overactivation in ...

Think of the brain as a city with traffic lights that keep signals flowing smoothly. In a new study, researchers followed a clue about nitric oxide, a common chemical messenger, and found that, in ...

Dedifferentiated liposarcoma lacks effective IGF-1→PPAR-γ adipogenic signaling due to epigenetic silencing of PPAR-γ2, with ...