A psychoactive ingredient found in ayahuasca, a brew used in shamanistic rituals in South America, has shown promise as a treatment for depression in a phase 2a trial. In the study, 34 people living ...

A single injection of N,N-dimethyltryptamine, the psychedelic compound found in ayahuasca, reversed depression-like symptoms in chronically stressed mice, according to a peer-reviewed study published ...

New research suggests that a single dose of the psychedelic compound DMT can reverse symptoms of depression, including loss ...

Tripping on psychedelics is hard to describe to someone who’s never been through the experience. Every psychedelic trip is ...

A new psychedelic retreat calling itself a “SETI for the mind” aims to establish two-way communication with the nonhuman entities people encounter while tripping on DMT.

Study finds participants saw reduction in depressive symptoms as researchers welcome ‘promising’ results A phase II clinical trial has found dimethyltryptamine (DMT), one of the psychoactive ...

Over the last few years, evidence has piled up that psychedelic drugs can provide relatively rapid relief from the symptoms of clinical depression. The drugs seemingly work by boosting the brain’s ...

Summary: While psychedelic research often focuses on hours-long “trips” with psilocybin or LSD, a landmark Phase IIa trial has proven that a much shorter experience can be just as potent. Using DMT, ...

Summary: For decades, the idea that the human brain naturally produces N,N-dimethyltryptamine (DMT)—often dubbed “The Spirit Molecule”—has been a cornerstone of psychedelic lore, linked to dreams and ...

A powerful psychedelic, best known for its intense but brief effects, may offer a new way to treat depression. In a Phase 2 clinical trial at Imperial College London, a single intravenous dose of ...

In an early clinical trial, a single dose of a short-acting psychedelic drug led to rapid improvement in people with major depressive disorder. "A single dose of DMT with psychotherapeutic support ...

Researchers find DMT – used in shamanic rituals – in tandem with psychotherapy has significant effect People with major depressive disorder can see a rapid and lasting improvement after a single dose ...