Researchers are piecing together the unusual chemical reactions that enable dinoflagellates to create spectacular light displays in tropical bays. But the mechanism behind their bioluminescence remain ...

1 Department of Respiratory Sciences, Centre for Fibrosis Research and Institute for Structural and Chemical Biology, University of Leicester, Leicester, UK 2 Institute for Lung Health and NIHR ...

The inhibitor and substrate compete for the same binding site (or the active site) on the enzyme. The inhibitor decreases the enzyme’s capacity to bind the substrate, but this impact may be ...

CHAMPAIGN, Ill. — A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination ...

University of Cincinnati Cancer Center researchers looked billions of years into the past to learn more about the potential future of precision medicine. Led by first author Bibek R. Karki and senior ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

This useful manuscript reports on the crystal structures of two glycosaminoglycan (GAG) lyases from the PL35 family, along with in vitro enzyme activity assays and comprehensive structure-guided ...