Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Cardiac sodium–calcium exchanger (NCX1), the dominant calcium (Ca) efflux mechanism in cardiomyocytes, is strongly regulated by pH. However, the physiological relevance of NCX1 pH regulation in ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

In skeletal muscle, calcium is not only essential to stimulate and sustain their contractions but also for muscle embryogenesis, regeneration, energy production in mitochondria, and fusion. Different ...

The control of muscle contraction is usually described in terms of excitation–contraction coupling or muscle activation. Muscle relaxation has received much less attention, although its control is ...

This month's cover highlights the article Sertm2 is a Conserved Micropeptide that Promotes GDNF-mediated Motor Neuron Subtype Specification by Jun-An Chen, Fang-Yu Hsu and colleagues. The micropeptide ...

Senior Editor; The University of Texas at Austin, United States Our editorial process produces two outputs: i) public reviews designed to be posted alongside the preprint for the benefit of readers; ...

ABSTRACT: Impaired excitation-contraction coupling occurs in eccentric contraction (ECC)-induced damaged muscles. It has been suggested that sarcoplasmic reticulum (SR) is susceptible to damage in the ...

Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP 3-receptor (IP 3 R) calcium channels are necessary for the mitochondrial Ca 2+ increase caused by membrane depolarization induced ...

The possibility that the inotropic action of epinephrine might be mediated through an effect on the excitation-contraction coupling process was explored, using techniques for measurement of isometric ...