Colchicine features a narrow therapeutic range, and intoxication may cause multiorgan dysfunction. We present a case of a man in his 70s who experienced an accidental colchicine overdose (11 mg over 2 ...

Abstract: Introduction: P-glycoprotein, an integral membrane transporter, is a critical gatekeeper in the absorption, distribution and elimination of a wide range of drugs and xenobiotics.

Copyright: © 2025 Published by Elsevier Ltd. This study's key strengths include its rigorous randomised controlled design, adequate sample size for a phase 1 trial ...

In Sarah Yuska’s sixth-grade science class at Monocacy Middle School in Frederick, Maryland, students are just finishing up learning about body systems—respiratory, circulatory, skeletal, and so on.

This is an important study that utilizes proteomic and genetic approaches to identify the glycoprotein quality control factor malectin as a pro-viral host protein involved in the replication of ...

In his decades-long career in tech journalism, Dennis has written about nearly every type of hardware and software. He was a founding editor of Ziff Davis’ Computer Select in the 1990s, senior ...

Center for Advanced Measurement Science, National Institute of Metrology, Beijing 100029, China ...

Differential glycosylation plays a key role in modulating glycoprotein functions by influencing protein interactions. In this study, we employed the GAP–MS platform to characterize glycan-dependent ...

In this valuable study, the discovery and subsequent design of the AF03-NL chimeric antibody led to a tool for studying filoviruses and provides a possible blueprint for future therapeutics. In ...