The start-up Function will send practically anyone to a lab for extensive medical testing, no physical required. Is that a good thing? By Kristen V. Brown As Kimberly Crisp approached middle age, ...

Abstract: Introduction: P-glycoprotein, an integral membrane transporter, is a critical gatekeeper in the absorption, distribution and elimination of a wide range of drugs and xenobiotics.

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Background: Right ventricular dysfunction (RVD) is a risk factor for death in PAH, but RV-specific therapies are lacking. We showed inhibition of glycoprotein 130 (GP130) signaling with the small ...

This is an important study that utilizes proteomic and genetic approaches to identify the glycoprotein quality control factor malectin as a pro-viral host protein involved in the replication of ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...

Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan ...

NLGP downregulates VEGF at 4 h transcriptionally and both VEGF and HIF1α at 18 h translationally. Co-factors of HIF1α-transcriptional-complex downregulated at 4 h in hypoxia by NLGP. Downregulation of ...