Background Gut bacteria have been implicated in a wide range of health conditions, yet their potential role in preventing and treating muscle-wasting disorders remains largely unexplored. Objective We ...

Cancer remains a leading cause of morbidity and mortality, although cancer survivorship has increased impressively in the past decades. Patients with cancer often face cardiovascular complications, ...

A circuit formed by tumor, immune and nervous systems triggers cancer cachexia and anorexia, the excessive loss of weight, muscle and fat experienced in some cancer types. A new study is the first ...

New research from the University of Oklahoma, published today in Cancer Cell, describes for the first time a "triangle regulation theory" of cancer-induced cachexia and anorexia. Cachexia is a ...

Immune checkpoint inhibitors (ICIs), including antibodies against the programmed cell death protein 1/ligand 1 (PD-1/L1) effectively at boost the immune system; however, they may cause immune-related ...

University of Houston researchers have identified a key cellular pathway involved in muscle wasting caused by pancreatic cancer, offering new insights into potential therapies. Cancer cachexia is not ...

Leukocyte populations and FcγR in mouse splenocytes displayed distinct expressional patterns when comparing across tumor and cachexia status. Univariate analyses revealed several correlations between ...

Across disciplines, therapeutic areas and even continents, Pfizer scientists have been working to advance understanding of – and potential treatments for – cachexia, a complex metabolic condition ...

Zaver Bhujwalla, vice chair of research and director of the Division of Cancer Imaging Research, has built her career around understanding the tumor microenvironment and developing imaging tools that ...

Ponsegromab treatment led to sustained weight gain and GDF-15 suppression over 64 weeks in cancer-associated cachexia patients. Patients initially on placebo gained weight after switching to ...