As populations age worldwide, the decline of the immune system, a process known as immunosenescence, has become a critical biomedical challenge. This decline leads to increased susceptibility to ...

An integrin mutation impairs skin T cell migration, enabling HPV proliferation that causes warts and lesions in a rare genetic dermatological condition.

Clinicians report high satisfaction with lifitegrast for improving ocular signs and symptoms of dry eye disease.

Secondary lymphoid organs, such as lymph nodes, harbor highly specialized and compartmentalized niches. These niches are optimized to facilitate the encounter of naive lymphocytes with antigens and ...

Gaucher disease (GD) is one of the most common lysosomal storage disorders. It is caused by bi-allelic mutations in the GBA1 gene responsible for the production of β-glucocerebrosidase, an enzyme ...

In a recent study published in Nature, researchers developed a blood nutrient molecule library and conducted screenings to find dietary components that impact anti-tumor immunity. Dietary nutrients ...

Lymphocytes are a type of white blood cell that play a critical role in the immune system. They help the body fight off infections and diseases, making it essential to maintain healthy lymphocyte ...

Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon ...

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 ...