Repair of open neural tube defects, including myelomeningocele, in the fetus has been shown to improve postnatal outcomes by decreasing the severity of hydrocephalus and, consequentially, reducing the ...

The authors used genetic mutations in VANGL2 to study cell morphological changes during differentiation of hPSCs and understand the mechanisms underlying neural tube closure defects. The findings are ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...

Lancet Phase 1 study finds in-womb stem cell therapy feasible and safe in spina bifida, supporting expansion to a larger clinical trial.

A Phase I clinical trial published in The Lancet has shown that combining stem cell therapy with standard fetal surgery before birth is a safe and promising approach to treat myelomeningocele, a ...

1 Department of Obstetrics & Gynecology, Onandjokwe Intermediate Hospital, Ministry of Health & Social Services, Oniipa, Namibia. 2 Department of Pediatrics, Faculty of Health Sciences, Lusaka Apex ...

Participants Babies with an NTD and pregnancy outcome of live birth, stillbirth (≥20 weeks’ gestation) or termination of pregnancy (any gestation), as recorded in the Scottish Linked Congenital ...

The main challenge of large-scale numerical simulation of radiation transport is the high memory and computation time requirements of discretization methods for kinetic equations. In this work, we ...