Lipid nanoparticle-delivered messenger RNA encoding anti-PD-L1 nanobodies has reduced tumour growth in sporadic and colitis-associated colorectal cancer models, with quadruple constructs that ...

Endogenous, or ‘self’, vs. microbial, or ‘non-self’, RNA sensing can tip the scales between immune pathology and effective immunity. Cells are equipped to sense RNA, fundamental to trigger an innate ...

A vascular dilatation in the aorta can be life-threatening if it bursts. These so-called aortic aneurysms typically form in the same sites of the large blood vessel: either on the upper arch or in the ...

1. A nucleoside-modified mRNA (modRNA) influenza vaccine showed greater protection against influenza-like illness compared to a standard inactivated vaccine in adults. 2. The modRNA vaccine triggered ...

The modRNA vaccine had superior relative efficacy against influenza-like illness, but more reactogenicity events. HealthDay News — A quadrivalent nucleoside-modified messenger RNA (modRNA) influenza ...

The relative efficacy of the modRNA vaccine was 34.5% against influenza-like illness compared with the control vaccine, on the basis of 57 and 87 cases in the modRNA and control groups, respectively; ...

Researchers found that the relative efficacy of the modRNA vaccine was 34.5% against influenza-like illness compared with the control vaccine, on the basis of 57 and 87 cases in the modRNA and control ...

Influenza remains an important cause of illness and death. In this phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine ...

Oligonucleotides have a wide range of applications in fields such as biotechnology, molecular biology, diagnosis and therapy. However, the spectrum of uses can be broadened by introducing chemical ...