Lipid nanoparticle-delivered messenger RNA encoding anti-PD-L1 nanobodies has reduced tumour growth in sporadic and colitis-associated colorectal cancer models, with quadruple constructs that ...
Endogenous, or ‘self’, vs. microbial, or ‘non-self’, RNA sensing can tip the scales between immune pathology and effective immunity. Cells are equipped to sense RNA, fundamental to trigger an innate ...
(A) PDL1Nb, CTLA-4, Luc pDNA construction. (B) IB analysis shows the levels of PDL1Nb or CTLA-4Nb in the SFM of HEK293 cells transfected with PDL1Nb, CTLA-4Nb or Luc expression vectors. Mock: SFM.
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