Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.

A protein’s life is anything but simple. Discover how transcription, translation, folding, modification, and degradation work together to preserve proteome integrity.

Researchers at the Max Delbrück Center show that two related enzymes, MNK1 and MNK2, act on the brain to regulate different behaviors.

Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

Calorie restriction improves muscle insulin sensitivity in aging rats, but males and females achieve this through different molecular pathways. Credit: Stock Eating less may rewire aging muscles in ...

ABSTRACT: Vacuolar H⁺-ATPase (V-ATPase), encoded by the ATP6V gene family, is an evolutionarily conserved, a multisubunit proton pump that plays a fundamental role in maintaining intracellular pH ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Center for BioAnalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale, University of Science and Technology of China, Hefei 230026, China Center for BioAnalytical Chemistry, ...

A healthy heart is able to modify its function and increase relaxation through post-translational modifications of myofilament proteins. While there are known examples of serine/threonine kinases ...

Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University, Columbus. (L.G.S., H.E.S., E.A.B., V.S., S.L.S., H.Z., B.T ...

Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a tiny fraction ...