This important paper presents a rigorous and comprehensive deep mutational analysis of the kinase TYK2, revealing how single amino acid substitutions influence protein abundance, signaling activity, ...

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A new computational method allows modern atomic models to learn from experimental thermodynamic data, according to a ...

The data is clear: teams with an xG advantage do not win every time. xG can reflect the quality of chances created, but it ...

Heat-related ED visits for extreme heat were generally higher in early summer than in late summer, suggesting the necessity to consider temporal changes in heat risk when developing nuanced and ...

Background Cardiovascular disease (CVD) is the leading cause of mortality worldwide, while depression is highly prevalent in this patient population and has long been regarded as an independent risk ...

Microsoft researchers have developed On-Policy Context Distillation (OPCD), a training method that permanently embeds ...

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Background We describe the occurrence of second primary lung cancers (SPLCs) and their determinant in Sweden. Methods Nation-wide cancer registry from years 1961 to 2021 identified a total of 853 ...

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Introduction Envision our digital world as a sprawling universe filled with glittering constellations of encrypted data, each packet of information ...

Cosmology is puzzled as to why two methods for measuring the expansion of the cosmos yield different results. A third method ...