为了让微小的RNA分子在冷冻电镜下“显形”，一种直观的思路是人为地给它们“增重”。在此前的研究中，人们尝试过将目标RNA（客体）共价连接到已知结构的巨型RNA分子（主体）上，例如使用长达250到400个核苷酸的I型或II型自剪接内含子作为支架。这种方法虽然取得了一定成效，但庞大的主体结构使得整个复合物变得过于臃肿，目标客体RNA在整个颗粒中只占据极小的比例，导致计算资源的大量消耗，且往往难以获得客 ...

A remarkably small bacterium containing fewer than 500 genes serves as the basis for one of the most detailed digital life ...

The research team used a 'new chemical strategy' to create plastic that would degrade naturally.

They’re tenacious, which is very good for a milk jug or a car bumper. But they don’t easily break down, which is bad for the environment. From the 1950s, when plastics were first produced in ...

Discover the molecular mechanisms behind severe blood clots linked to specific COVID-19 vaccines, revealing crucial insights for future vaccine safety.

Greetings from Day 2 of the CHDI HD Therapeutics Conference! HDBuzz continues to provide summaries of the exciting talks from HD scientists gathered in Palm Springs from around the world. This day’s ...

This article explains how diet creates sustained epigenetic changes that affect long-term health, disease risk, aging, and ...

Ongoing research aims to confirm the mechanism by which ICP4 fluidizes the nucleus, which could indicate specific targets to counter viral replication.

Bismuthene nanodiscs use mild heat to switch on gene editing that dismantles a tumor's heat defenses, creating a feedback loop that kills cancer cells more effectively.

Herpes simplex virus partially liquifies the tightly packed, gel-like interior of human cell nuclei to copy itself faster, a new study shows.

The cold season is in full swing, throats are scratchy and noses are running. We feel ill and hope it is not the flu. The ...

A common type of error-correcting mechanism in biology is called kinetic proofreading. For example, if errors turn up when cells are making new DNA, enzymes can cut out incorrect nucleotides. They can ...