通过 GFAP 启动子驱动的 AAV-PHP.eB 载体，经外周静脉注射即可在小鼠脑内实现 CAR 在星形胶质细胞的稳定表达。单次注射后，CAR-A 在淀粉样斑块周围持续存在达 3 个月。 在 6 月龄 5xFAD 小鼠中，治疗 3 个月后淀粉样负荷降低约 50%，皮层与海马斑块明显减少，不溶性 Aβ42 下降，神经突营养不良改善。早期干预几乎完全阻止 Aβ ...

Tau proteins play an important role in Alzheimer's disease. Tau helps to stabilize neurons in the brain, but in Alzheimer's disease, tau proteins can misfold and tangle inside neurons. These tangles ...

Tau proteins play an important role in our normal brain function, mainly by helping to stabilize neurons in the brain. But in Alzheimer’s disease, tau proteins can misfold and tangle inside neurons.

A series of converging advances in bio-implant technology, from brain-spine interfaces to lab-grown spinal tissue, is bringing the long-elusive goal of spinal cord repair closer to clinical reality.

Researchers use AI and postmortem tissue to reveal that tau PET scans are often influenced by iron and neuroinflammation rather than tau tangles alone.

Researchers from the NeuroAD group (Neuropathology of Alzheimer's Disease) within the Department of Cell Biology, Genetics and Physiology at the University of Málaga, also affiliated with ...

The progressive loss of function and structure of neuronal cells is a process that falls under the name "neurodegeneration." Regardless of their etiology, ...

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Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...