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「NR」Swern oxidation 斯文氧化——药明康德常考反应
用DMSO和TFAA或草酰氯氧化一级醇或二级醇生成醛或酮的反应,就称为swern oxidation (斯文氧化)。 1976年,D. Swern等报道了二甲基亚砜(DMSO)在-50℃以下与三氟乙酸酐(TFAA)在二氯甲烷中反应生成三氟乙氧基二甲基磺基三氟乙酸酯,并与一级醇和二级醇快速反应。
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