Scientists have identified a critical breakdown in the cellular machinery that produces proteins in aging brains.

Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a protein and alter its function. A team at HZB has now investigated the Nsp1 ...

A recent study by Fred Hutch biochemist Christopher Lapointe, PhD, and his colleagues, uses innovative lab techniques to ...

The origin of the nucleus remains hotly debated among scientists, but new imaging and genomic data are shedding light on this billion-year-old mystery.

Under stress, animal cells pair inactive ribosomes into RNA-linked disomes. A ribosomal RNA “kissing loop” joins them, protecting ribosomes and reducing protein synthesis to conserve energy.<br /> ...

Neurons have a "hibernation mode." Scientists discover how brain cells use RNA tentacles to lock their protein factories together to survive when energy is low.

Ribosomes, the cell's protein-making factories, consume large amounts of energy as they build the proteins that keep cells alive and functioning. When cells experience stress—such as lack of nutrients ...

Ribosomes are large molecular machines made of protein and RNA that build all proteins in the cell. Because protein production is extremely energy-intensive, cells rapidly reduce protein synthesis ...

Ribosomes—the tiny factories that build proteins in our cells—don't all work with the same efficiency. Researchers from Japan have discovered that ribosomes actually compete with one another, and ...

Bacterial ribosomes are central to protein synthesis, and their regulation is vital for adaptation to environmental stresses. Under conditions such as nutrient deprivation, cold shock or hypoxia, ...

This study focuses on a previously reported positive correlation between translational efficiency and protein noise. Using mathematical modeling and analysis of experimental data the authors reach the ...