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Plant steroid hormones, brassinosteroids (BRs), are perceived by a cell surface receptor kinase, BRI1, but how BR binding leads to regulation of gene expression in the nucleus is unknown. Here we ...

Official implementation of Generative Flows on Synthetic Pathway for Drug Design by Seonghwan Seo, Minsu Kim, Tony Shen, Martin Ester, Jinkyu Park, Sungsoo Ahn, and Woo Youn Kim. [paper] RxnFlow are a ...

Scientists are finally tracing, step by step, how bacteria strip down and rebuild steroid molecules into compounds that look a lot like modern drugs. By mapping these microbial assembly lines in the ...

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School of Chemistry and Chemical Engineering, Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, No. 928, No. 2 Street, Xiasha ...

Panelists discuss how specialists balance controlling chronic graft-vs-host disease (cGVHD) symptoms while minimizing steroid exposure when patients fail initial therapy. In the clinical case, ...

Panelists discuss how steroid dosing for chronic graft-vs-host disease (cGVHD) typically starts at 0.5-1 mg/kg/day depending on severity, with careful tapering to avoid flares. Dr Bishop: 1 mg/kg/day ...

Pregnane X Receptor (PXR, NR1I2) is a ligand-dependent transcription factor belonging to the nuclear receptor superfamily, that can be activated by a wide variety of endogenous and exogenous ligands.