SINGAPORE – Hotel Properties Limited (HPL), owned by real estate magnate Ong Beng Seng, is expected to post a net loss for the financial year ended Dec 31, 2025. Despite higher revenue, finance costs ...

在靶向蛋白降解领域，爱思益普生物公司的平台在STAT6靶点研究中取得了显著突破。STAT6是信号转导与转录激活因子6，主要介导IL - 4和IL - 13的细胞信号传导，在过敏反应和抗寄生虫免疫中起核心作用，是过敏性疾病中TH2炎症的核心驱动因素，靶向STAT6具有广阔的 ...

在靶向蛋白降解（TPD）药物研发中，复合物形成实验是全面表征蛋白与配体之间相互作用，以及与E3连接酶形成三元复合物能力的关键环节。爱思益普生物公司的TPD平台在这一方面展现出了卓越的技术优势，为药物研发提供了精准的数据支持。 爱思益普采用光谱 ...

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We may receive a commission on purchases made from links. If you want to carry an easily concealable high-powered flashlight like those used by agents of the Federal Bureau of Investigation (FBI), ...

A 3D virtual model of the PKMYT1–PROTAC–CRBN ternary complex depicting how Insilico Medicine’s bifunctional proteolysis-targeting chimera (PROTAC) D16-M1P2 (shown in yellow) inhibits ...

Harbor Freight Tools was hit with a trademark and patent infringement lawsuit on June 26 in Delaware District Court over allegations it copied Streamlight's distinctive 'Ring Mark' design for ...

Having already stripped back their development plans for the estrogen receptor (ER) degrader vepdegestrant on the back of mixed data, Pfizer and Arvinas have now decided to wash their hands of the ...

In order for robots to operate safely around humans, they need to see that people are approaching and they need to know when they make physical contact with those people. A new system allows them to ...

The smaller market now envisioned for vepdegestrant “doesn’t move the dial for Pfizer” in terms of the original 50-50 collaboration, and that agreement isn’t “particularly attractive for Arvinas ...

This repository contains the program code to split PROTAC molecules into their constituent substructures. A Gradio app is available to split PROTAC molecules and ...

Sacituzumab govitecan (SG) + pembrolizumab (pembro) vs chemotherapy (chemo) + pembro in previously untreated PD-L1–positive advanced triple-negative breast cancer (TNBC): Primary results from the ...