Expansion microscopy enabled researchers to count the number of connections between neurons (green points on purple neuron). Neurons exposed to amyloid-beta formed more connections (SSBs = single ...

Loss and dysfunction of synapses have been linked to age-related cognitive decline and observed in Alzheimer's and other ...

Synaptic pruning is a crucial neurodevelopmental process through which the brain refines its neural circuitry by systematically eliminating excess or weak synaptic connections. During early childhood ...

Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

How do we learn something new? How do tasks at a new job, lyrics to the latest hit song, or directions to a friend’s house become encoded in our brains? The broad answer is that our brains undergo ...

Astrocytes in the cerebellum trigger a shift in GABA signaling during late adolescence, enabling adult-level motor coordination.