Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer ...

Expansion microscopy enabled researchers to count the number of connections between neurons (green points on purple neuron). Neurons exposed to amyloid-beta formed more connections (SSBs = single ...

目前的遗传学证据表明，ASD风险涉及许多与突触功能、染色质重塑和免疫调节相关的位点，常见的下游效应集中在炎症途径和小胶质细胞功能障碍上。这种破坏最终会损害突触体内平衡，代表了ASD发病机制中遗传和神经免疫机制的临界点。

Loss and dysfunction of synapses have been linked to age-related cognitive decline and observed in Alzheimer's and other ...

A Northwestern Medicine study has uncovered novel cellular mechanisms within the retina, findings that could help advance the development of targeted therapeutics for diseases and conditions impacting ...

Synaptic pruning is a crucial neurodevelopmental process through which the brain refines its neural circuitry by systematically eliminating excess or weak synaptic connections. During early childhood ...

Insights from advanced imaging technology show how neurons communicate at the atomic level for the first time. For the first time, scientists at The Hospital for Sick Children (SickKids) used advanced ...

Astrocytes in the cerebellum trigger a shift in GABA signaling during late adolescence, enabling adult-level motor coordination.