A structural protein best known for building the internal scaffolding of cells may double as a natural defense against the ...

Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...

A new paper, published in Science Translational Medicine, investigated whether levetiracetam, an anti-seizure medication, could form the basis for innovative drug treatments for Alzheimer’s disease.

The 2.6-million-square-foot Terminal One, part of a multibillion-dollar redevelopment of Kennedy Airport, will be nearly as large as the Empire State Building. The 2.6-million-square-foot Terminal One ...

Neurodegenerative disorders, most notably Alzheimer’s disease (AD), are marked by progressive cognitive decline and widespread neuronal loss. A growing body of evidence indicates that synaptic ...

Science and Technology on Electronic Test and Measurement Laboratory, North University of China, Taiyuan 030051, China State Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement ...

Sustained synaptic transmission requires the continuous replenishment of released synaptic vesicles (SVs). This process is particularly critical in neuronal circuits that operate at high rates and ...

Progressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).

Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. In this manuscript, ...