Why depression treatment still feels like educated guesswork Major depressive disorder is diagnosed based on how a person feels and functions, not on what shows up in a lab test or scan. Two patients ...

Researchers have discovered a surprising change in how cells produce energy in people with depression. Brain and blood cells in young adults with major depressive disorder produced more energy ...

A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression. Researchers tracked changes in a critical brain receptor ...

A surprising energy imbalance in the brain and blood cells may offer a new way to detect and treat depression earlier.

Major depressive disorder (MDD) is a major global health problem and one of the leading causes of disability. About 30% of people diagnosed with ...