What is lipodermatosclerosis? It is a form of chronic panniculitis primarily caused by venous insufficiency. Lipodermatosclerosis results from chronic venous hypertension due to incompetent valves or prior DVT resulting in deep venous insufficiency. It is exacerbated by prolonged standing, sedentary lifestyle and aging. This leads to inflammation, fibrin cuff formation around capillaries, tissue hypoxia, and progressive fibrosis of the subcutaneous fat and dermis on the lower legs. Dr. Hratch Ka