Brain cancer remains one of the most complex and least understood cancers. While clear risk factors haven’t been defined, we do know that the brain is highly sensitive to hormonal balance. It’s one of the body’s most active sites of steroid synthesis—glial cells can produce hormones like progesterone, pregnenolone, and even small amounts of estrogen. These locally made neurosteroids regulate inflammation, protect neurons, and stabilize energy metabolism. When this hormonal environment becomes im