11K views · 494 reactions | The link between NSAIDs & Acute Kidney...
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11K views · 494 reactions | The link between NSAIDs & Acute Kidney...
Entice. Entice · Original audio. The link between NSAIDs & Acute Kidney Injury (AKI) we can't ignore. Ever prescribed a common painkiller and seen a patient's creatinine levels rise? Here’s a quick breakdown of the pharmacology behind it. 🧠 The Mechanism: Normal Function: Prostaglandin E2 (PGE2) keeps the afferent arteriole (the "entry ...
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NSAIDs Side Effects
Long-term NSAID side effects: discuss with your doctor to make sure the benefits outweigh the risks. 🩺 Stomach ulcers NSAIDs block COX-1 prostaglandins that protect the stomach lining (mucus, bicarbonate, blood flow), and they can directly irritate the mucosa. Long-term users have substantial rates of endoscopic ulcers and “silent” injury. PMID: 39327242, 37053160, 3048080, 27713351 🩸 Internal bleeding Less mucosal protection plus impaired platelet aggregation increases GI bleeding risk. Bleed
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Long-term NSAID side effects: discuss with your doctor to make sure the benefits outweigh the risks. 🩺 Stomach ulcers NSAIDs block COX-1 prostaglandins that protect the stomach lining (mucus, bicarbonate, blood flow), and they can directly irritate the mucosa. Long-term users have substantial rates of endoscopic ulcers and “silent” injury. PMID: 39327242, 37053160, 3048080, 27713351 🩸 Internal bleeding Less mucosal protection plus impaired platelet aggregation increases GI bleeding risk. Bleed
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