Video: Conjugate Addition of Enolates: Michael Addition
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Video: Conjugate Addition of Enolates: Michael Addition
2.7K Views. The attack of a nucleophile at the β carbon of an α,β-unsaturated carbonyl compound is called conjugate addition. Conjugate addition reactions of active methylene compounds, such as β-diketones, β-keto esters, β-keto nitriles, and α-nitro ketones, are called Michael addition reactions. The reaction is ca...
2023年3月3日
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SOLVED:Formulate a detailed mechanism for the Michael addition process just depicted. Why is the base required in only catalytic amounts?
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Explain the importance of Michael addition in organic chemistry... | Filo
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2 个月之前
askfilo.com
SOLVED:Formulate a detailed mechanism for the Michael addition process just depicted. Why is the base required in only catalytic amounts?
SOLVED:Formulate a detailed mechanism for the Michael additio…
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Organic Name Reactions on Instagram: "The Michael addition enables the conjugate (1,4-) addition of carbon nucleophiles to α,β-unsaturated compounds, forming new C–C bonds via attack at the β-carbon. Typical C-nucleophiles include enolates, stabilized carbanions (e.g., malonates, β-dicarbonyls, etc.), and organocuprates. First described by Arthur Michael in the late 19th century, the reaction proceeds through enolate addition to the activated alkene followed by protonation, favoring thermodynami
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