Long-term NSAID side effects: discuss with your doctor to make sure the benefits outweigh the risks. 🩺 Stomach ulcers NSAIDs block COX-1 prostaglandins that protect the stomach lining (mucus, bicarbonate, blood flow), and they can directly irritate the mucosa. Long-term users have substantial rates of endoscopic ulcers and “silent” injury. PMID: 39327242, 37053160, 3048080, 27713351 🩸 Internal bleeding Less mucosal protection plus impaired platelet aggregation increases GI bleeding risk. Bleed

20K views · 217 reactions | When searching for over-the-counter pain relief, you've probably taken an NSAID medication, such as ibuprofen or naproxen. But what kind of pain does an NSAID treat best and are there risks of side effects?https://mayocl.in/2rMpsgq | Mayo Clinic | Facebook